Trojanowski and colleagues chart epigenetic changes linked to Alzheimer's

Trojanowski and colleagues chart epigenetic changes linked to Alzheimer's

NIA Aging Centers News Reference

"'Epigenetic landscape' is protective in normal aging, impaired in Alzheimer's disease" - Science Daily. 03/05/2018.

New research out of the University of Pennsylvania suggests that Alzheimer's disease is linked to specific chromatin shifts in the aging brain. PARC's John Trojanowski and colleagues found evidence that in AD brains cellular responses to stress and DNA damage are dysregulated by a change in a histone protein. The authors say their findings "point to a new model of Alzheimer’s disease" and open the possibility that "prevention of age-dysregulation at the chromatin level may be a therapeutic avenue for AD."

Researcher Profile:
John Q. Trojanowski (U-Penn)

More Information:

Article in Nature Neuroscience

Additional Media Coverage:

"Postmortem Analyses Point to Distinct Epigenetic Features in Aging Alzheimer's Brains" - GenomeWeb. 3/5/2018.

"An Epigenetic Link Between Aging and Alzheimer's" - Technology Networks. 3/7/2018.

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